Our Solution
Services
Reliable, successful and highly reproductive mass spectrometric services are transforming biotherapeutics quality assessment. We perform charge variant analysis using an electrokinetically pumped sheath-flow nanospray ion source EMASS-II and a time-of-flight MS. The sample submitted could be solid/powder or liquid.
cIEF-MS
Capillary Isoelectric Focusing-Mass Spectrometry, for the separation and online characterization of charge variants. The sample could be: mAb, BsAb, ADC, Fusion Protein, or other custom sample.
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Truly pl - based separation
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High resolution separation on peptides and proteins
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Separation based on isoelectric focusing equilibrium
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Use ampholytes
CZE-MS
Capillary Zone Electrophoresis-Mass Spectrometry, for the separation and online characterization of charge variants. The sample could be: mAb, BsAb, ADC, Fusion Protein, or other custom sample.
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Homogeneous solution (no pH gradient)
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Complex separation mechanism
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Partially affected by charges, but not pl - based
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No ampholytes
Service Features
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Characterization: flexibility in CR3520-cIEF-MS workflow, length of the separation capillary can be adjusted
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Risk free: we offer refunds on labor in the rare case that analysis is not successful
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Timeline: normally 2 weeks turnaround
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Deliverables: show a chart of "identified charge variants of NISTmAb"