Our Solution

Services

Reliable, successful and highly reproductive mass spectrometric services are transforming biotherapeutics quality assessment. We perform charge variant analysis using an electrokinetically pumped sheath-flow nanospray ion source EMASS-II and a time-of-flight MS. The sample submitted could be solid/powder or liquid.

cIEF-MS

Capillary Isoelectric Focusing-Mass Spectrometry, for the separation and online characterization of charge variants. The sample could be: mAb, BsAb, ADC, Fusion Protein, or other custom sample.

  • Truly pl - based separation

  • High resolution separation on peptides and proteins

  • Separation based on isoelectric focusing equilibrium

  • Use ampholytes

CZE-MS

Capillary Zone Electrophoresis-Mass Spectrometry, for the separation and online characterization of charge variants. The sample could be: mAb, BsAb, ADC, Fusion Protein, or other custom sample.

  • Homogeneous solution (no pH gradient)

  • Complex separation mechanism

  • Partially affected by charges, but not pl - based

  • No ampholytes

Service Features

  • Characterization: flexibility in CR3520-cIEF-MS workflow, length of the separation capillary can be adjusted

  • Risk free: we offer refunds on labor in the rare case that analysis is not successful

  • Timeline: normally 2 weeks turnaround

  • Deliverables: show a chart of "identified charge variants of NISTmAb"